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Saturday, February 8, 2020 | History

6 edition of Design and synthesis of organic molecules based on molecular recognition found in the catalog.

Design and synthesis of organic molecules based on molecular recognition

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  • 6 Currently reading

Published by Springer-Verlag in Berlin, New York .
Written in English

    Subjects:
  • Bioorganic chemistry -- Congresses.,
  • Binding sites (Biochemistry) -- Congresses.,
  • Molecular association -- Congresses.,
  • Molecular recognition -- Congresses.,
  • Organic compounds -- Synthesis -- Congresses.

  • Edition Notes

    Includes bibliographies.

    Statementedited by Georges van Binst ; chairmen of the conference, Ephraim Katchalski-Katzir and Vladimir Prelog.
    ContributionsBinst, Georges van, 1934-
    Classifications
    LC ClassificationsQP514.2 .S58 1983
    The Physical Object
    Paginationxv, 315 p. :
    Number of Pages315
    ID Numbers
    Open LibraryOL2548330M
    ISBN 100387161236
    LC Control Number85030319

    Bioorganic Chemistry from Northeastern University, Boston. In: Shank N. Regular surfaces can be used for the construction of self-assembled monolayers and multilayers. These other molecules may be used to derive a pharmacophore model that defines the minimum necessary structural characteristics a molecule must possess in order to bind to the target. The Nobel Laureates in Chemistry have miniaturized machines and taken chemistry to a new dimension. Based on the information gained from fundamental studies of molecular recognition, biophysics, and supramolecular chemistry, new drug analogues can be synthesized to exhibit altered binding properties with desired biological effects.

    Jin, Y. He has published 1, scientific papers and trained more than graduate and postdoctoral students. Selective high affinity binding to the target is generally desirable since it leads to more efficacious drugs with fewer side effects. Arya earned his B. He has been working for more than three decades on using this growing understanding to develop template-directed protocols that rely upon such processes to create artificial molecular machines.

    Here, the author covers two aspects of this ongoing effort. The complexation of bipyridines or terpyridines with rutheniumsilver or other metal ions is of great utility in the construction of complex architectures of many individual molecules. On the other hand it should not be so broad that it can not be covered during the limited time of the conference. Bioorganic Chemistry from Northeastern University, Boston. The template for host construction may be subtly different from the guest that the finished host binds to.


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Design and synthesis of organic molecules based on molecular recognition book

After construction, the template is removed leaving only the host. Carbohydrate chemistry: The synthesis of sugars and oligosaccharides using synthetic or biosynthetic methodologies for studying biological processes such as disease states, vaccines, and cell recognition phenomena Supramolecular Chemistry: The study of molecular recognition and host-guest interactions, the design and synthesis of supramolecular motifs, including coordination compounds, molecular, and polymeric assemblies for use in biological systems and medicine.

The molecules are able to identify each other using non-covalent interactions. Molecular self-assembly[ edit ] Molecular self-assembly is the construction of systems without guidance or management from an outside source other than to provide a suitable environment.

At the same time he is strong believer in a global scientific community that transcends the borders that separate nations. The University is proud of his many accomplishments.

Gram-negative synergy and mechanism of action of alkynyl bisbenzimidazoles. His work on molecular recognition and self-assembly and his subsequent introduction of template-directed routes to mechanically interlocked molecules has changed dramatically the way chemists go about making soft materials.

Using the structure of the biological target, candidate drugs that are predicted to bind with high affinity and selectivity to the target may be designed using interactive graphics and the intuition of a medicinal chemist.

Print ISBN: A major current goal in zeolite chemistry is to create a structure in which metal ions and functionalizable organic units make up an integral part of the framework.

One such enzyme target under investigation is the bacterial Topoisomerase I. Supramolecular metallocycles are macrocyclic aggregates with metal ions in the ring, often formed from angular and linear modules. Template-directed synthesis is a special case of supramolecular catalysis.

An example of current focus of the laboratory is to understand the features that differentiate B-form from A-form DNA and use this knowledge to discover and design molecules that can specifically recognize A-and B-form DNA.

Supramolecular chemistry

The study of such molecules requires their synthesis. In: Shank N. Medicine[ edit ] Design based on supramolecular chemistry has led to numerous applications in the creation of functional biomaterials and therapeutics. Thus most of the bottom-up approaches to nanotechnology are based on supramolecular chemistry.

The template may be as simple as a single metal ion or may be extremely complex.

Molecular machine

This idea was successful and proved to be quite fruitful; within the last 5 years over 90 new ZIF structures have been reported.

The first is referred to as ligand -based drug design and the second, structure-based drug design. Similar tools are being applied to the recognition of other higher order DNA and RNA structures, such as triplexes and quadruplexes.

These devices exist at the boundary between supramolecular chemistry and nanotechnologyand prototypes have been demonstrated using supramolecular concepts. New methods of organic synthesis are in constant need and some syntheses are designed search for or explore new reactions.

Self-assembly may be subdivided into intermolecular self-assembly to form a supramolecular assemblyand intramolecular self-assembly or folding as demonstrated by foldamers and polypeptides.

DNA has been used both as a structural and as a functional unit in synthetic supramolecular systems. In practice it still takes several iterations of design, synthesis, and testing before an optimal drug is discovered.

These aluminosilicate-based materials represent a large segment of the global economy. For structure-based drug design, several post-screening analyses focusing on protein-ligand interaction have been developed for improving enrichment and effectively mining potential candidates: Selecting candidates by voting of multiple scoring functions May lose the relationship between protein-ligand structural information and scoring criterion Represent and cluster candidates according to protein-ligand 3D information Needs meaningful representation of protein-ligand interactions.

Other units, such as benzidine derivatives, viologensand fullerenesare useful in supramolecular electrochemical devices.Calixarene-Based Receptors for Molecular Recognition. between organic molecules and calixarenes and their deriv atives. Synthesis of calixarene-based ketocyanine fluorophores.

The main goal of this chapter is to reveal the importance of molecular structure analysis with specific computational tools using quantum chemistry methods based on density functional theory (DFT) with focus on pharmaceutical compounds. A wide series of molecular properties and descriptors related with chemical reactivity is discussed and compared for small organic molecules (e.g., quinolones Cited by: 1.

Synthetic Receptors for Biomolecules covers the most effective synthetic receptors for each major class of biomolecules within the context of specific applications.

The book starts with an introduction to the applications of synthetic receptors for biomolecules and their. @article{osti_, title = {Influence of Multi-Valency, Electrostatics and Molecular Recognition on the Adsorption of Transition Metal Complexes on Metal Oxides: A Molecular Approach to Catalyst Synthesis}, author = {Rioux, Robert M.}, abstractNote = {In this work, we have primarily utilized isothermal titration calorimetry (ITC) and complimentary catalyst characterization techniques to.

A protocol for supramolecular synthesis of one-dimensional (1-D) chains comprising octahedral metal-complexes linked by predictable hydrogen bonds has been established.

The synthetic process was refined by adjusting the reactants in an iterative manner to shift the magnitude of the electrostatic potential surfaces of competing hydrogen-bond acceptor sites thereby avoiding the formation of Cited by: 6. 3. Self-assembly of 2D and 3D Organic Crystals. In collaboration with Steve Tait, we are investigating the design rules that control the organization of molecules under conditions of dynamic self-assembly when they order on graphite sylvaindez.com take advantage of molecular design to test how the information encoded into the molecules dictate their packing on the surface.